abstract：PURPOSE:To evaluate whether repetitive optokinetic stimulation with active pursuit eye movements leads to substantial and greater recovery from visual neglect as compared to conventional visual scanning training. METHODS:Two groups of five patients with leftsided hemineglect were consecutively collected and matched fo...

journal_title：Restorative neurology and neuroscience

authors： Kerkhoff G,Keller I,Ritter V,Marquardt C

更新日期：2006-01-01 00:00:00

abstract：PURPOSE:Immunomodulatory agents are often combined in organ transplantation to minimize toxicity and enhance therapeutic effect. We hypothesized that combining low-dose FK506 with anti-CD40 Ligand (anti-CD40L mAb) would enhance regeneration through peripheral nerve allografts while preserving immune unresponsiveness. ...

journal_title：Restorative neurology and neuroscience

authors： Brenner MJ,Mackinnon SE,Rickman SR,Jaramillo A,Tung TH,Hunter DA,Mohanakumar T

更新日期：2005-01-01 00:00:00

abstract：PURPOSE:The relationship between auditory temporal-order perception and phoneme discrimination has been discussed for several years, based on findings, showing that patients with cerebral damage in the left hemisphere and aphasia, as well as children with specific language impairments, show deficits in temporal-process...

journal_title：Restorative neurology and neuroscience

authors： Fink M,Churan J,Wittmann M

更新日期：2005-01-01 00:00:00

abstract：PURPOSE:Although many previous studies have indicated that the acute inflammatory response following traumatic brain injury (TBI) is detrimental, inflammation may also positively influence outcome in the more chronic post-injury recovery period. We evaluated the effects of monoclonal antibodies (mAB), neutralizing eith...

journal_title：Restorative neurology and neuroscience

authors： Marklund N,Keck C,Hoover R,Soltesz K,Millard M,LeBold D,Spangler Z,Banning A,Benson J,McIntosh TK

更新日期：2005-01-01 00:00:00

abstract：PURPOSE:Study the effect of peripheral nerve extracts and BDNF on retinal ganglion cell (RGC) regeneration in adult rats. METHODS:Postmicrosomal fractions were obtained from 7-day, predegenerated, as well as non-predegenerated peripheral adult rats nerves. Autologous connective tissue chambers filled with fibrin were ...

journal_title：Restorative neurology and neuroscience

authors： Swiech-Sabuda E,Gołka B,Kotulska K,Larysz-Brysz M,Górka D,Gołka D,Marcol W,Lewin-Kowalik J

更新日期：2004-01-01 00:00:00

abstract：:Basic science studies demonstrated mechanisms of plasticity and metaplasticity. More recent human studies identified some of these mechanisms as operating in multiple areas of human cognition, such as learning and memory, and in functional recovery from lesions in the CNS, as in stroke. One of the goals of neurorehabi...

journal_title：Restorative neurology and neuroscience

authors： Celnik PA,Cohen LG

更新日期：2004-01-01 00:00:00

abstract：PURPOSE:We wished to evaluate the efficacy of vision restoration therapy (VRT) in patients with post-chiasmatic brain damage using different functional perimetric tests. These were compared with measures of subjective vision and reaction time. METHODS:An open trial was conducted with hemianopia/scotoma (n=16) patients...

journal_title：Restorative neurology and neuroscience

authors： Sabel BA,Kenkel S,Kasten E

更新日期：2004-01-01 00:00:00

abstract：PURPOSE:Contralateral primary sensori-motor cortex (SM1) activation by passive movement was investigated by functional MRI (fMRI) at the early stage of stroke, to determine whether SM1 activation can be used to predict the degree of motor recovery of the hemiplegic hand. METHODS:We studied 17 stroke patients who showe...

journal_title：Restorative neurology and neuroscience

authors： Jang SH,Kim YH,Chang Y,Han BS,Byun WM,Chang CH

更新日期：2004-01-01 00:00:00

abstract：PURPOSE:To analyze the effects of CGP 3466, a compound structurally related to deprenyl, on survival and function of fetal ventral mesencephalic dopaminergic neurons. METHODS:Free-floating roller tube (FFRT) cultures of rat (E14) ventral mesencephalon were treated with CGP 3466 [10-8 M] for 7 days. Tyrosine hydroxylas...

journal_title：Restorative neurology and neuroscience

authors： Matarredona ER,Meyer M,Seiler RW,Widmer HR

更新日期：2003-01-01 00:00:00

abstract：PURPOSE:Ischemic stroke is associated with a variety pathophysiological changes affecting both glial and neuronal brain tissue. These changes are mirrored in the release of specific proteins into peripheral blood. Neurone-specific enolase (NSE), protein S100B and glial fibrillary acidic protein (GFAP) are those protein...

journal_title：Restorative neurology and neuroscience

authors： Herrmann M,Ehrenreich H

更新日期：2003-01-01 00:00:00

abstract：INTRODUCTION:Traumatic brain injuries (TBI) are one of the most common consequences of traffic accidents. Patients with mild, moderate or severe brain injuries suffer from physical, cognitive, behavioral, emotional and social problems. Most of these problems have been a long standing focus amongst practitioners and res...

journal_title：Restorative neurology and neuroscience

authors： Bullinger M,Azouvi P,Brooks N,Basso A,Christensen AL,Gobiet W,Greenwood R,Hütter B,Jennett B,Maas A,Truelle JL,von Wild KR,TBI Consensus Group.

更新日期：2002-01-01 00:00:00

abstract：:Embryonic stem (ES) cells have the ability to differentiate into a variety of cell lineages. We are examining ES cell differentiation in vitro by using cDNA microarrays to generate a molecular phenotype for each cell type. El4 ES cells induced by retinoic acid after forming embryoid bodies differentiate almost exclusi...

journal_title：Restorative neurology and neuroscience

authors： Loring JF,Porter JG,Seilhammer J,Kaser MR,Wesselschmidt R

更新日期：2001-01-01 00:00:00

abstract：PURPOSE:Many studies have investigated the roles of neurotrophic factors in nerve regeneration by examining either anatomical recovery (regenerated axon count) or functional recovery as measured by sensory and motor behavior. This longitudinal study examined the effects of NGF and NT3 on functional and anatomical recov...

journal_title：Restorative neurology and neuroscience

authors： Young C,Miller E,Nicklous DM,Hoffman JR

更新日期：2001-01-01 00:00:00

abstract：:The lamination of dentate gyrus afferents established during development is maintained following lesion-induced reactive growth in the adult. After partial deafferentation sprouts from undamaged afferents restore most synapses, while respecting the laminae relative boundaries. No evidence of trans-laminar sprouting ha...

journal_title：Restorative neurology and neuroscience

authors： Collazos-Castro JE,Nieto-Sampedro M

更新日期：2001-01-01 00:00:00

abstract：:Over the past few decades astrocytes have emerged from being considered simple packing tissue in the brain to become major players in the development, survival and functioning of central nervous system (CNS) neurons. As the influence that astrocytes (and the various molecules they produce) have on the development of C...

journal_title：Restorative neurology and neuroscience

authors： Gates MA,Dunnett SB

更新日期：2001-01-01 00:00:00

abstract：PURPOSE:Exogenously applied BDNF has been shown to rescue rat retinal ganglion cells (RGCs) from axotomy-induced apoptotic death, presumably via activation of its high affinity receptor TrkB. Since both TrkB and BDNF are endogenously expressed in RGCs, auto- or para-crine neurotrophic loops in the retina may be involve...

journal_title：Restorative neurology and neuroscience

authors： Hirsch S,Labes M,Bähr M

更新日期：2000-01-01 00:00:00

abstract：:Purpose: Damage of primary visual cortex in adult humans, monkeys and cats severely disrupts vision by disconnecting much of the cogni-tive processing machinery of extrastriate cortex from its source of visual signals in the retina. Equivalent lesions sustained early in life result in partial sparing of visual process...

journal_title：Restorative neurology and neuroscience

authors： Payne BR,Lomber SG

更新日期：2000-01-01 00:00:00

abstract：:Purpose: Caspase-3 is known as a crucial effector for apoptotic cell death. Apoptosis has recently been recognized as an important cell death mechanism after spinal cord injury (SCI). This study attempts to define the effect of methylprednisolone (MP) on the activation of caspase-3 in the lesioned area following SCI. ...

journal_title：Restorative neurology and neuroscience

authors： Li X,Oudega M,Dancausse HA,Levi AD

更新日期：2000-01-01 00:00:00

abstract：:PURPOSE: Nerve allografts are highly antigenic and, thus, require the continuous use of immunosuppressive drugs. FK 506 was found to pre-vent rejection successfully. However, clinically neurotoxic complications have been noted in the central and peripheral nervous system although an increased rate of axonal regenerati...

journal_title：Restorative neurology and neuroscience

authors： Fansa H,Keilhoff G,Horn T,Altmann S,Wolf G,Schneider W

更新日期：2000-01-01 00:00:00

abstract：:Various basic qualitative and quantitative methods for the evaluation of sensorimotor functions after Traumatic Brain Injury (TBI) are introduced and discussed. Methodological aspects are illustrated by a single case follow-up study of a child after severe TBI (age 11; 7–12;1 yrs; 6, 8 and 12 month post TBI) in compar...

journal_title：Restorative neurology and neuroscience

authors： Jöhnk K,Kuhtz-Buschbeck JP,Stolze H,Serocki G,Kalwa S,Ritz A,Benz B,Illert M

更新日期：1999-01-01 00:00:00

abstract：:PURPOSE: Until recently, there has been a limited amount of research comparing functional and anatomical recovery following nerve injury. Previous studies emphasizing anatomical recovery (such as axonal number) have shown that testosterone promotes regeneration in crushed and transected nerves. The purpose of this stu...

journal_title：Restorative neurology and neuroscience

authors： Swallow RK,Leiser MR,Fink BE,Sauer C,Nicklous DM,Hoffman JR

更新日期：1999-01-01 00:00:00

abstract：:Retinal and cortical lesions are completely different events that trigger visual cortical plasticity. We therefore compared the cortical effects of homonymous lesions of the central retina with effects of cortical lesions. All in vivo experiments were performed in anaesthetized, adult cats. Retinal lesions were made w...

journal_title：Restorative neurology and neuroscience

authors： Eysel UT,Schweigart G,Mittmann T,Eyding D,Qu Y,Vandesande F,Orban G,Arckens L

更新日期：1999-01-01 00:00:00

abstract：:The authors used different kinds of peripheral nerve grafts to reconstruct a terminal branch of the brachial plexus (the median nerve) gap of adult Sprague-Dawley rats, including fresh or frozen autografts and allografts from Norway rats. They also performed acellular allograft repopulation by autogenous Schwann cells...

journal_title：Restorative neurology and neuroscience

authors： Accioli-De-Vaconcellos ZA,Kassar-Duchossoy L,Mira JC

更新日期：1999-01-01 00:00:00

abstract：:Traumatic brain and spinal cord injuries are severe burdens for the patients, their relatives, the health care providers and society as a whole. Recent data demonstrate the magnitude of the problem: It is mostly a disease of the young gen-eration (age 20-45 years) with mortality rates for severe traumatic brain injury...

journal_title：Restorative neurology and neuroscience

authors： Neugebauer E,Lefering R,Noth J

更新日期：1999-01-01 00:00:00

abstract：:A long-term goal in motor rehabilitation is that treatment is not selected on the basis of 'schools of thought', but rather, based on knowledge about efficacy and effectiveness of specific interventions for specific situations (e.g. functional syndromes). Motor dysfunction after stroke or TBI can be caused by many dif...

journal_title：Restorative neurology and neuroscience

authors： Platz T,Hesse S,Mauritz KH

更新日期：1999-01-01 00:00:00

abstract：:Injury of the nervous system initiates a cascade of signal transduction including a rise in extracellular glutamate which leads to subsequent secondary neuronal loss. Excitotoxicity is known to play a crucial role in cell death spinal cord trauma. Gangliosides, particularly monosialogangliosides (GM1), are protective ...

journal_title：Restorative neurology and neuroscience

authors： Vorwerk CK,Bonheur J,Kreutz MR,Dreyer EB,Laev H

更新日期：1999-01-01 00:00:00

abstract：:The hypothesis that a destabilization of mitochondrial function during neuronal exposure to excitatory amino acids may be involved in the mechanism of neuronal death was examined. The mitochondrial membrane potential (Delta(psi)m) and the cytoplasmic Ca2+ concentration ([Ca2+]c) were monitored simultaneously in single...

journal_title：Restorative neurology and neuroscience

authors： Kiedrowski L

更新日期：1998-06-01 00:00:00

abstract：:Melatonin (MLT) is a methoxyindole secreted principally by the pineal gland. It is synthesized at night under normal environmental conditions. The endogenous rhythm of secretion is generated by the suprachiasmatic nuclei and entrained by the light/dark cycle. Light is able to both suppress or synchronize melatonin pro...

journal_title：Restorative neurology and neuroscience

authors： Claustrat B,Brun J,Geoffriau M,Chazot G

更新日期：1998-06-01 00:00:00

abstract：:To examine the regeneration capacity of dorsal septohippocampal neurons in the presence of an artificial growth-promoting substrate, biocompatible polymeric hydrogels were implanted between the septum and the hippocampus in a fimbria-fornix lesion cavity. Unmodified (control) or aminosugar-containing (glucosamines or ...

journal_title：Restorative neurology and neuroscience

authors： Duconseille E,Woerly S,Kelche C,Will B,Cassel JC

更新日期：1998-01-01 00:00:00

abstract：:Administration of gangliosides accelerates recovery of function after entorhinal cortex lesions on open field activity and learned spatial alternation tasks. In the present study, we examined whether GM1 ganglioside might enhance recovery from bilateral entorhinal cortex lesions on a differential reinforcement of low-...

journal_title：Restorative neurology and neuroscience

authors： Ramirez JJ,MacDonald K,Mañibo J,Payne J,Tuite C

更新日期：1998-01-01 00:00:00

abstract：:The response of astroglial cells in the hippocampus to long-term portacaval anastomosis (PCA), an experimental model of hepatic encephalopathy, was studied in adult male rats and compared with controls. Six months after PCA, the rat hippocampi were processed for glial fibrillary acidic protein (GFAP). GFAP-immunoposit...

journal_title：Restorative neurology and neuroscience

authors： Suarez I,Bodega G,Fernandez B

更新日期：1998-01-01 00:00:00

abstract：:Following brain injury there is an excessive release of glutamate, a reduction in levels of cellular Mg+ +, and the generation of oxygen free radicals. These processes may contribute to the severity of the behavioral impairments seen following brain injury by leading to secondary neuronal degeneration. The present exp...

journal_title：Restorative neurology and neuroscience

authors： Hoane MR,Raad C,Barth TM

更新日期：1997-01-01 00:00:00

abstract：:Bridging large defects in mixed nerves is still an unsolved problem in reconstructive microsurgery. Two main aspects may be distinguished: one is to obtain an appropriate substitute for the lost neural tissue, the second to direct fibers toward their previous end-organs with the highest possible specificity. In the pr...

journal_title：Restorative neurology and neuroscience

authors： Papaloïzos MY,Holmquist B,Lundborg G

更新日期：1997-01-01 00:00:00

abstract：:In four patients with left visuo-spatial hemineglect and right brain- damage, the therapeutic effects of Transcutaneous Electrical Nervous Stimulation (TENS) of the left neck muscles, associated with a non-specific treatment, and of a specific rehabilitation paradigm were investigated. The two treatments were given fo...

journal_title：Restorative neurology and neuroscience

authors： Pizzamiglio L,Vallar G,Magnotti L

更新日期：1996-01-01 00:00:00

abstract：:Regenerating nerve fiber sprouts enveloped by olfactory bulb (OB) ensheathing cells (ECs) seem to escape the inhibitory influence of gliotic tissue. Accordingly, these cells may be useful for general repair of injured CNS. Relatively large numbers of ECs could be purified from confluent cultures of adult rat olfactory...

journal_title：Restorative neurology and neuroscience

authors： Gudiño-Cabrera G,Nieto-Sampedro M

更新日期：1996-01-01 00:00:00

abstract：:Many toxic factors are generated during stroke that contribute directly to the death of neurons. Several recent studies suggest that a suicide-like phenomena similar to apoptosis or programmed cell death also contributes to the loss of neurons in stroke. The evidence implicating apoptosis in stroke can be divided into...

journal_title：Restorative neurology and neuroscience

authors： Linnik MD

更新日期：1996-01-01 00:00:00

abstract：:Fetal neocortical block transplants were implanted into the excitotoxically ablated sensorimotor cortex of adult rats in order to examine the density of innervation and distribution of presumptive host derived afferent fibers within these transplants. Cholinergic fiber innervation was examined at 3 months post graftin...

journal_title：Restorative neurology and neuroscience

authors： Schulz MK,McNulty JA,Hogan TP,Zimmer J,Castro AJ

更新日期：1995-01-01 00:00:00

abstract：:The objective of this study was to develop an optimal dissection procedure for fetal porcine ventral mesencephalon (VM) grafts and to characterize the cellular composition of such an explant, in particular with respect to the dopaminergic and GABAergic components. We have used a monolayer cell culture system to study ...

journal_title：Restorative neurology and neuroscience

authors： van Roon WM,Copray JC,Hogenesch RI,Kema I,Meyer EM,Molenaar G,Lugard C,Staal MJ,Go KG

更新日期：1995-01-01 00:00:00

abstract：:Animals with unilateral neurotoxic lesions in the striatum exhibit a stereotypical biased rotational behavior in response to dopamine agonists. We recently argued that the rotational test may be subject to sensitization effects of the drug. Accordingly, we proposed the drug-free elevated body swing test (EBST) as an a...

journal_title：Restorative neurology and neuroscience

authors： Borlongan CV,Cahill DW,Sanberg PR

更新日期：1995-01-01 00:00:00

abstract：:It is widely accepted that the suprachiasmatic nuclei (SCN) of the hypothalamus serve as biological pacemakers, organizing daily activities. However some circadian rhythms are controlled by extra-SCN structures. Transplantation of fetal donor SCN in SCN-lesioned rodents induces recovery of rhythmic locomotor and drink...

journal_title：Restorative neurology and neuroscience

authors： Le Sauter J,Silver R

更新日期：1994-01-01 00:00:00